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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TSC2 All Species: 23.03
Human Site: S377 Identified Species: 50.67
UniProt: P49815 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49815 NP_000539.2 1807 200608 S377 Q Q L Q T L D S P E L R T I V
Chimpanzee Pan troglodytes XP_523477 1803 200189 S377 Q Q L Q T L D S P E L R T I V
Rhesus Macaque Macaca mulatta XP_001083256 1807 200600 S377 Q Q L Q T L D S P E L R T I V
Dog Lupus familis XP_852047 1813 201226 S377 H Q L Q S L D S P E L R A I V
Cat Felis silvestris
Mouse Mus musculus Q61037 1814 202053 S377 Q Q L Q N L D S P E L K T I V
Rat Rattus norvegicus P49816 1809 201259 S377 Q Q L Q N L D S P E L R T I V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516748 947 107028
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_695912 1128 123244
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524177 1847 204101 H379 I N K D R L H H L Q I N F H E
Honey Bee Apis mellifera XP_395739 1813 206229 T374 E T S N Q P A T R Q V S V N L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786931 1947 217345 H383 N I E Y A V S H E Y L P T Q L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 97.9 91.2 N.A. 88.9 91 N.A. 44.1 N.A. N.A. 35.8 N.A. 29.8 38.2 N.A. 31.1
Protein Similarity: 100 99 99 94.6 N.A. 92.2 93.9 N.A. 48.3 N.A. N.A. 44.3 N.A. 49.7 58.6 N.A. 48.9
P-Site Identity: 100 100 100 80 N.A. 86.6 93.3 N.A. 0 N.A. N.A. 0 N.A. 6.6 0 N.A. 13.3
P-Site Similarity: 100 100 100 86.6 N.A. 93.3 93.3 N.A. 0 N.A. N.A. 0 N.A. 20 33.3 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 10 0 10 0 0 0 0 0 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 10 0 0 55 0 0 0 0 0 0 0 0 % D
% Glu: 10 0 10 0 0 0 0 0 10 55 0 0 0 0 10 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 10 0 0 0 0 0 10 19 0 0 0 0 0 10 0 % H
% Ile: 10 10 0 0 0 0 0 0 0 0 10 0 0 55 0 % I
% Lys: 0 0 10 0 0 0 0 0 0 0 0 10 0 0 0 % K
% Leu: 0 0 55 0 0 64 0 0 10 0 64 0 0 0 19 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 10 10 0 10 19 0 0 0 0 0 0 10 0 10 0 % N
% Pro: 0 0 0 0 0 10 0 0 55 0 0 10 0 0 0 % P
% Gln: 46 55 0 55 10 0 0 0 0 19 0 0 0 10 0 % Q
% Arg: 0 0 0 0 10 0 0 0 10 0 0 46 0 0 0 % R
% Ser: 0 0 10 0 10 0 10 55 0 0 0 10 0 0 0 % S
% Thr: 0 10 0 0 28 0 0 10 0 0 0 0 55 0 0 % T
% Val: 0 0 0 0 0 10 0 0 0 0 10 0 10 0 55 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 10 0 0 0 0 0 10 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _